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		<title>Customer Q &#8211; A on Dianabol bulking and cutting Cycle</title>
		<link>http://dianabol.us/steroids-info/customer-steroids-questions/</link>
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		<pubDate>Wed, 03 Feb 2010 05:32:27 +0000</pubDate>
		<dc:creator>Paul</dc:creator>
				<category><![CDATA[customer questions]]></category>
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		<description><![CDATA[Many customers are unaware how to incorporate anabolic steroids into a proper bulking or cutting cycle. You can send us your questions in cycling, dianabol, sustanon, winstrol and other steroids and pct therapy and we will reply to asap. ]]></description>
			<content:encoded><![CDATA[<p><font color="#808080"><strong>Hi xx,</p>
<p>Got a quick question. I want to take anavar towards the end of my dianabol cycle&#8230;&#8230;&#8230;&#8230;then I want to take clomid at the end of the anavar cycle to keep my gains. Would the anavar act as an estrogen blocker so I wouldn&#8217;t get gyno? Basically what I&#8217;m doing is taking 30mg of dbols for 7 weeks. On the 5th week I am going to incorporate the anavar. Then when the anavar is done I will take the clomid to keep my gains. What do you think? I do not want gyno.</strong></font></p>
<p><strong><br />
<font color="#800080">Hello xxx,</p>
<p>the anavar will not stop any possible estrogen effects of the dbols, that is a myth, so i would recommend to start clomid with 50-100mg/day right the next day (week 5) when you stop your dbols&#8230;.</font></strong></p>
<div align="center">
<p><img width="200" vspace="10" height="178" align="middle" src="/images/steroid_hulk.jpg" alt="hulk on steroids" /></p>
</div>
<p><span id="more-259"></span></p>
<p align="left"><font color="#808080"><strong>The effect is that it will reduce the circulating estrogen and get the water out of your body and lead to higher definition. Perfect to accompany this also from 5th week on then with the anavars as these will aid even more in leaning you out.</strong></font></p>
<p><strong><font color="#800080"> <br />
With cutting, you should use lower weights with lots of repetions, and aswell adjust to a leaner diet, all contrary from the bulking that you do with the dbols, during that time you have to eat like a small horse to see the best conversion and hit the weights with all you got. yeah!<br />
After cutting period do only maintainence lifting once or twice a week or cardio workout, besides that, dont lift hard, until your next bulking cycle. Generally i would recommend you injectables for the future, as they are healthier for the liver, result in more effective and longer lasting gains.<br />
cheers<br />
xx</font></strong></p>
<hr width="100%" size="2" align="left" />
<p align="left"><font color="#808080"><strong>Hi xx, <br />
</strong></font></p>
<p align="left"><strong><font color="#808080">i was recently asking you about some steroid tablets and been looking into dianabol, winstrol, turanabol tabs. How would it work if i do a cycle of all these together? </font></strong></p>
<p align="left"><strong><font color="#800080">Hello xxxx,</p>
<p>lets see, well i would always recommend injectables over tablets, however you could experiment with these 3 (tbol, winnie,dbol) but you wont be able to distinguish the difference as you take them all together and you dont have enough for separate complete cycles of just one substance to make a judgement.. so if you go with tabs then do winnie+dbols, or only t-bols,. the result will pretty much be the same IMO. Dont use any of these tablets for longer than 6-8 weeks at a time, and get some milk thistle tabs over the counter and use these along to keep your liver healthy..</font></strong></p>
<p align="left"><strong><font color="#800080">cheers</font></strong></p>
<p align="left"><strong><font color="#800080">xx</font></strong></p>
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		<title>Anabolic Steroids Injections &#8211; #2 Injection Sites</title>
		<link>http://dianabol.us/steroids/anabolic-steroids-injections-2-injection-sites/</link>
		<comments>http://dianabol.us/steroids/anabolic-steroids-injections-2-injection-sites/#comments</comments>
		<pubDate>Tue, 05 May 2009 16:22:30 +0000</pubDate>
		<dc:creator>Paul</dc:creator>
				<category><![CDATA[howto inject steroids]]></category>
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		<description><![CDATA[So where do you inject steroids properly ??

&#160;
Glute Injections: The best way to locate the correct place for dosing is to find the upper outer quadrant (section) of the butt cheek you are injecting into. Inject only into the upper outer area of the quadrant &#8211; which muscle you actually inject into is less significant. [...]]]></description>
			<content:encoded><![CDATA[<h3><strong>So where do you inject steroids properly ??</strong></h3>
<p style="text-align: center;"><img hspace="8" height="164" align="left" width="200" vspace="8" alt="Steroid injections" src="http://dianabol.us/wp-content/uploads/glute_injection.gif" /></p>
<p>&nbsp;</p>
<p><strong>Glute Injections</strong>: The best way to locate the correct place for dosing is to find the upper outer quadrant (section) of the butt cheek you are injecting into. Inject only into the upper outer area of the quadrant &#8211; which muscle you actually inject into is less significant. It is important to avoid the other quadrants because they can be very sensitive to needle injection and there is a chance to hit large veins and/or nerves.&nbsp;</p>
<p>&nbsp;</p>
<p><img hspace="8" height="332" align="right" width="100" vspace="8" alt="howto inject steroids" src="http://dianabol.us/wp-content/uploads/thigh_injection.gif" /></p>
<p><strong>Thigh Injections:</strong> The injection spot is generally located on the front outside area of the thigh between one hand&rsquo;s width above the knee and one hand&rsquo;s width below the hip joint. The injection should go into the thick area of the large muscle to be sure to stay away from any bone.</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p><strong>Deltoid Iniection:</strong> Insert the needle at a 90-degree angle, or slightly angled up, into the middle of the deltoid muscle. This is approximately 2-4 finger-widths below the bony end of your shoulder bone and forms a triangle when you look at it from the side.</p>
<p style="text-align: center;"><img height="196" align="left" width="350" alt="steroids injection sites" src="http://dianabol.us/wp-content/uploads/delt_injection.gif" /></p>
<p>&nbsp;</p>
<p>
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		<title>Anabolic Steroids Injections &#8211; #1 Needles, Syringes</title>
		<link>http://dianabol.us/steroids/anabolic-steroids-injections-1-needles-syringes/</link>
		<comments>http://dianabol.us/steroids/anabolic-steroids-injections-1-needles-syringes/#comments</comments>
		<pubDate>Sun, 03 May 2009 14:45:09 +0000</pubDate>
		<dc:creator>Paul</dc:creator>
				<category><![CDATA[howto inject steroids]]></category>
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		<description><![CDATA[How To Inject Anabolic Steroids
It&#8217;s pretty funny the amount of questions you hear about how to inject steroids. Some of the most unbelievable stories you would ever hear. This is why I felt it was important to have this chapter in the book. People injecting steroids like its heroin, right into the vein! Or even [...]]]></description>
			<content:encoded><![CDATA[<p><strong>How To Inject Anabolic Steroids</strong></p>
<p>It&rsquo;s pretty funny the amount of questions you hear about how to inject steroids. Some of the most unbelievable stories you would ever hear. This is why I felt it was important to have this chapter in the book. People injecting steroids like its heroin, right into the vein! Or even more unbelievable, I&rsquo;ve heard stories of guys injecting HOG right into their scrotum because they want to stimulate their balls to produce more testosterone NOW! Trust me, this wont do anything but put you in the hospital.</p>
<p>For the most part anabolic steroids are injected using the IM (intramuscular) method. Typically, a large muscle, such as the gluteus muscle, is used so that pain is minimal and circulation of that steroid is more widespread. Much controversy exists about the site of injection, and whether it&rsquo;s important or unimportant. In my estimation, it&rsquo;s less about whether one site is better than the other for delivery, and more about whether site injections are at all effective in creating specificity of growth in that area. I&rsquo;ll go into that more later.</p>
<p style="text-align: center;"><img height="214" width="200" alt="how to inject steroids" src="http://dianabol.us/wp-content/uploads/how_to_inject_steroids.jpg" /></p>
<p><strong>Needle Size</strong><br />
The gauge of a needle is its size in diameter (around). Depending upon what you&rsquo;re taking, you&rsquo;ll either choose a smaller or larger needle to get the job done. It&rsquo;s impossible to use just one size needle for everything because oil and water-based injections require different sizes. So, unless you always take Winstrol Depot and Testosterone Suspension, you&rsquo;re probably going to need a larger needle for your oil-based injections, like Deca and Primobolan Depot. But here&rsquo;s the trick: The higher the number, the smaller the needle. A 22 gauge needle is smaller than a 17 gauge needle. Might I say, I don&rsquo;t know if anyone uses a 17 gauge needle because it&rsquo;s huge like a salami, but it&rsquo;s just an example.</p>
<p><span id="more-100"></span><br />
For drugs like Winstrol V (water based compounds with larger particles), and most oil-based drugs, use a 22-23 gauge needle to accommodate the solids.</p>
<p>For drugs like Winstrol Depot, with a finer grade of particle, you can jump up to a 25 gauge needle.</p>
<p>For insulin injections, site injections using fine particle water-based drugs, use as high as a 27 or 28 gauge needle. These are insulin needles, by classification, and are the best as far as pain goes.</p>
<p><strong>Needle Length</strong><br />
Needles come in various lengths: 112&rdquo;, 518&rdquo;, 1&rdquo;, 1.5&rdquo;. Some veterinary needles come in 2&rdquo; lengths, but unless you&rsquo;re very fat, you won&rsquo;t want to use something that plunges into the muscle quite that deep. Which brings me to the point of this chapter&hellip; you choose a needle length based on two things: Size of muscle group and amount of subcutaneous fat you must go through in order to reach a reasonable depth within the muscle. Generally, because the glute muscle is a larger muscle group, you&rsquo;ll most often want to use it for injections, It can handle larger particles, multi-drug dosing and a 1.5&rdquo; needle. If you&rsquo;re in the off-season, use a 1&rdquo; to 1.5&rdquo; needle to go through the fat you&rsquo;re carrying between competitions. Gradually decrease the length the leaner you get.</p>
<p><strong>Multi-drug Dosing</strong><br />
Sometimes people stack their oil-based drugs in one syringe to avoid multiple injections on a given day. If you want to do that you&rsquo;ll need to use a needle that has a larger gauge and a larger ml capacity. I recommend using actual veterinary syringes with your chosen gauge attached. This will allow you to load up with a larger than 3ml capacity, as with a standard human syringe. A veterinary syringe holds twice as much. Many people don&rsquo;t know how to get these, but they can be obtained through veterinary catalogs quite easily, or on veterinary wholesale sites online. You should be careful when you have needles in your possession though, even if they are for &ldquo;Vet&rdquo; uses. Some states require you get a prescription before you can possess needles and some states have needle exchange programs (NEP&rsquo;s) that you can participate in anonymously. The laws aren&rsquo;t all that clear about whether having them in your possession is legal or not in most cases. You will have to check the laws in your state to be sure, and even then you should be very careful. A lot of times they say that possessing a needle is legal, but then when you are caught, they confiscate it and test for drugs that are inside it. All they have to do is have probable cause to bust you and if they see a needle, they have probable cause.</p>
<p><span style="font-size: medium; "><span style="color: rgb(153, 51, 102); "><strong>Where to order securely needles and syringes for steroid injections ??</strong></span></span></p>
<p>Needles and syringes are usually not banned items. In many US states you can walk in a drugstore and buy these over the counter. In europe you can do the same in many countries.&nbsp;</p>
<p>If you have to order over the internet, for USA customers, there is one website that is in business long time and has low prices and sure delivery:&nbsp;</p>
<p>http://www.gpzservices.com/</p>
<p>&nbsp;</p>
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		<title>Newbie Help with Anabolic Steroids</title>
		<link>http://dianabol.us/steroids/newbie-help-with-anabolic-steroids/</link>
		<comments>http://dianabol.us/steroids/newbie-help-with-anabolic-steroids/#comments</comments>
		<pubDate>Wed, 29 Apr 2009 12:14:43 +0000</pubDate>
		<dc:creator>Paul</dc:creator>
				<category><![CDATA[bodybuilding]]></category>
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		<description><![CDATA[Tip 1 &#8211; Do Your Research.
This is INCREDIBLY important. First, keep in mind that the accuracy of anything you read online will only be about 90% &#8211; that includes this article. Although much of my research has come from scientific papers and other very knowledgeable individuals &#8211; I can&#8217;t 100% say that anything, even the [...]]]></description>
			<content:encoded><![CDATA[<p><strong>Tip 1 &#8211; Do Your Research.</strong></p>
<p>This is INCREDIBLY important. First, keep in mind that the accuracy of anything you read online will only be about 90% &#8211; that includes this article. Although much of my research has come from scientific papers and other very knowledgeable individuals &#8211; I can&#8217;t 100% say that anything, even the research experiments, are perfectly sound all of the time. You&#8217;ll have lots of self procalimed experts saying completely different things. One expert said that Nolvadex is useless to use as part of post cycle therapy and likened it to using suntan lotion in a snowstorm. Another expert said it is the preferred choice over it&#8217;s &quot;weaker counterpart&quot; clomid. Some experts will tell you that simple testosterone only cycles are best for the first cycle, while others will say that in order to optimize the benefits of any steroid cycle, you must properly stack any injectable steroids with their oral counterparts. I am a believer that testosterone should be the base of any steroid use, especially for those who have interest in doing further cycles in the future.</p>
<p style="text-align: center;">&nbsp;<img height="174" width="200" src="http://dianabol.us/wp-content/uploads/steroids_workout.jpg" alt="steroids help" /></p>
<p>The main reason a testosterone only cycle is recommended for the first time users is because it is the building block of all future cycles &#8211; if it isn&#8217;t &#8211; it should be! By using testosterone initially you will get an idea of how your body will react to it. You will need to know if you are prone to gyno, how much fluid you will retain and how much your blood pressure will raise with the use of anabolic steroids as part of your training and nutrition program. These are very important things to be aware of.</p>
<p><span id="more-95"></span></p>
<p>Think about it like this &#8211; you&#8217;re doing a stack of testosterone enanthate and dianabol &#8211; you feel the signs and symptoms of gyno coming along. So you fix the problem by taking by taking 20-30 mg of Nolvadex or 100 mg of Clomid (which you intelligently kept on hand) daily until the problem subsides and a few days after just to be safe. So the next time you cycle &#8211; you use only testosterone enanthate to avoid the aromotization problems brought upon by the addition of the dianabol tabs the first time out. But guess what? It wasn&#8217;t the test that was aromatizing after all &#8211; it was the dianabol. Now with testosterone only, you are still getting the signs and symptoms of gyno and must once again control the substance with use of an anti estrogen. Had you known you were gyno prone with the testosterone you could have better planned this second cycle and worked out a stack to your advantage and possibly even eliminated or greatly reduced the risks of re-ocurring gyno. If you start cycling with a stack, you won&#8217;t have any way of knowing which steroids are causing which side effects.</p>
<p>Another reason why testosterone only is a good first cycle &#8211; it&#8217;s your first cycle! Why go overkill? You&#8217;ll grow like a weed off testosterone only with correct nutrition and training &#8211; hell, even without it! In a study done by Bhasin and co-workers1, men with no weight training whatsoever made increases in fat-free mass (4KG or 8.8 lbs), increases in triceps mass (400 mm or 1.6&quot;), increases in quadriceps mass (600 mm or 2.4&quot;), and added 10KG (22.2 lbs) on their bench press and 20KG (44.4 to their squat. It&#8217;s TESTOSTERONE after all. You&#8217;re injecting HORMONES into yourself. Don&#8217;t let the quantity fool you &#8211; a mL of cyanide will kill you the same way as minimal amounts of steroids will make you grow. Your virgin androgen receptors will eat it up. Why use more when you&#8217;ll get the same results off less? What&#8217;s the point? It&#8217;s just a big waste of time and money. The last thing you want to do is develop a tolerance so that you are required more quantity in the future.</p>
<p>Testosterone may be a strong androgen, but the side effects are very easily controlled for almost all of them with a few simple ancillaries.</p>
<p>With any steroids you take you are going to shut down your natural testosterone production and this can lead to short term impotence and testicular atrophy (short term if your post cycle therapy is sound!). Deca and Trenbolone are not the only ones that cause this (any drug can when not accompanied by testosterone). Deca and Trenbolone are just the most common and most complained about for this type of thing.</p>
<p style="text-align: center;"><img height="182" width="200" src="http://dianabol.us/wp-content/uploads/testosterone_E300.jpg" alt="testosterone enanthate" /></p>
<p><strong>Tip 2 &#8211; Dbol should be stacked for best and lasting results</strong></p>
<p>There are plenty of good reasons for this &#8211; Obviously in that Dianabol is a 17-alpha alkylated steroid, warranting short-term use. Since Dianabol has little Androgen receptor activity, it functions particularly synergistic with compounds that have a strong Androgen receptor activity as is the case for all the aforementioned. In other words &#8211; stack it! Forgetting about the science here &#8211; do you want to make muscle, strength and water gains and end up feeling pumped and huge by the end of your cycle only to realize that the dianabol mainly gained you water and a few weeks after the cycle you lose it all?</p>
<p>Dianabol is a methylated compound with a certain toxicity, so in the interest of safety you wouldn&#8217;t use it longer than 6 weeks on end, 8 weeks at the absolute maximum and only under supervision of a medical professional who can monitor your liver values. Arnold was said to use it for eight weeks at a time (of course this is only speculation), but even if this was the case, Arnold was on a whole other level than most beginners. Don&#8217;t copy what he did and expect the same results &#8211; his workouts, nutrition program and steroid stacks were designed for his body and his genetics &#8211; never copy him or anybody else for that matter. Dianabol heavily aromatizes so its not particularly useful during cutting and with 6-8 weeks of use maximum, that leaves the option open &#8211; Stack it with another, injectable, compound that can be used for longer terms (beginning of stack when other compound is least active).</p>
<p>Dianabol is mainly meant to kick start your cycle gains. This is normally done by stacking it with a longer acting product, such as testosterone enanthate or cypionate, deca or equipose. For best use, include it early in a stack (see sample stack #2 listed below). You would run it with your 500mg of sustanon weekly as follows:</p>
<p>Weeks 1-4: Dianabol &#8211; 20-25 mg daily.</p>
<p>This should be more than sufficient for a beginner and just fine to kickstart your mass gains. Sometimes less is more! When it comes to 17-alpha alkylated drugs, this is one of those times. Liver health is something that you should be very important to you.</p>
<p>When stacking with a longer-acting product, such as testosterone enanthate or cypionate, Deca or Equipoise, the best use is early on in the stack. Dianabol is a very fast-acting steroid and most injectables don&#8217;t start showing their real value for 2-3 weeks. That makes it particularly useful to kick off a cycle with.</p>
<p>Source: bodybuildingpro.com</p>
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		<title>Steroids Key Terms Explained</title>
		<link>http://dianabol.us/steroids/steroids-key-terms-explained/</link>
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		<pubDate>Tue, 28 Apr 2009 13:01:33 +0000</pubDate>
		<dc:creator>Paul</dc:creator>
				<category><![CDATA[bodybuilding]]></category>
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		<description><![CDATA[TYPES OF STEROIDS
Anabolic/Androgenic Steroids can be roughly classified into two types, oral and injectable. When you eat food or consume anything orally, the great majority of the ingested substances pass through the liver prior to entering the bloodstream. For this reason, &#34;injectable&#34; AAS cannot be taken orally because the liver will deactivate the steroids in [...]]]></description>
			<content:encoded><![CDATA[<p><span style="background-color: rgb(102, 102, 153);"><span style="color: rgb(255, 255, 255);">TYPES OF STEROIDS</span></span></p>
<p>Anabolic/Androgenic Steroids can be roughly classified into two types, oral and injectable. When you eat food or consume anything orally, the great majority of the ingested substances pass through the liver prior to entering the bloodstream. For this reason, &quot;injectable&quot; AAS cannot be taken orally because the liver will deactivate the steroids in this &quot;first pass&quot;. Deactivation in the liver usually involves the addition of one or more hydroxyl (OH) groups to increase the solubility of the molecule in water, making excretion in the urine more easily accomplished.</p>
<p style="text-align: center;"><img height="146" width="200" alt="steorids info" src="http://dianabol.us/wp-content/uploads/body_building.jpg" /></p>
<p><span style="background-color: rgb(192, 192, 192);"><span style="color: rgb(255, 255, 255);">Oral Steroids</span></span></p>
<p>Oral steroids involve modification of the parent steroid to make it harder for the liver to degrade the steroid molecules. This modification is almost always the addition of an alkyl (methyl) group at the 17 position of the steroid ring. The liver can still degrade the steroid, but not as effectively as the un-modified steroid. Therefore, oral steroids make several cycles through the bloodstream before being excreted. Most oral steroids are, to various degrees, excreted from the body unchanged.</p>
<p><span style="background-color: rgb(192, 192, 192);"><span style="color: rgb(255, 255, 255);">Injectable Steroids</span></span></p>
<p>The injectable AAS are very effectively degraded in just a single pass through the liver. If this is so, then how can the injectables be effective? The answer is called a &quot;depot&quot; (or reservoir), which allows a regular release of steroid into the bloodstream. As steroid is removed from the bloodstream by the liver, more steroid is being released into the bloodstream from the depot. There are several ways to provide such a reservoir of the steroid.</p>
<p><span id="more-89"></span></p>
<p><span style="background-color: rgb(192, 192, 192);"><span style="color: rgb(255, 255, 255);">Suspension</span></span></p>
<p>The first way is to use pure testosterone (a crystalline solid) suspended in water. Testosterone has a low solubility in water, and the crystals slowly dissolve in the watery environment of the tissue in which it is injected. The dissolved testosterone is carried throughout the body by the bloodstream. For Testosterone suspension, the &quot;depot&quot; is the actual physical site where the injection is made. The crystals do not migrate to other parts of the body, and the presence of the crystalline testosterone can cause some pain at the injection site. The testosterone dissolves at a (relatively) constant rate, and lasts for a few days in the body. Winstrol suspension is similar.</p>
<p><span style="background-color: rgb(192, 192, 192);"><span style="color: rgb(255, 255, 255);">Esters</span></span></p>
<p>The other way to provide a depot of steroid is to use a water-insoluble form of the steroid that can be converted in the body to the parent steroid, which has some solubility in water (bloodstream). Most commonly, the parent molecule is esterified with an organic acid, and the resulting ester is soluble in oil, but only very slightly soluble in water. Commonly used organic acid groups are acetate (C2), propionate (C3), enanthate (C7), decanoate (C10), and undecylenate (C11). The longer the carbon chain of the acid, the more oil-soluble the ester, and the longer it takes for the ester to turn into the parent steroid (de-esterification). A type of enzyme that is found throughout the body facilitates the de-esterification reaction to form the parent steroid from the ester. The enzyme actually catalyzes the reaction in both directions, so it can also attach an organic acid back onto the parent steroid. So, for example, testosterone enanthate can actually be turned into testosterone palmitate. There is some good evidence that steroid esters are, to some extent, stored in fat cells. It is commonly believed that esters form a depot of oil/ester that stays at the injection site. This is not true. While the depot concept holds true for esters (because they slowly release the parent steroid over time), the esters actually disperse throughout the body after injection, prior to (and during) the de-esterification reaction to form the parent steroid. They do not stay at the injection site. For example, the ester testosterone enanthate has been found in tissues throughout the body, including hair samples of subjects who have injected T200. If a bio-contaminant is introduced at the time of injection (non-sterile conditions), the body will attempt to encapsulate the contaminated material, and an abscess will form. In this case it appears as if the ester has remained at the injection site. But under normal sterile conditions, the oily solution will disperse. Injecting too much at one site or injecting too frequently at one site will not cause an abscess.</p>
<p style="text-align: center;"><img height="244" width="200" src="http://dianabol.us/wp-content/uploads/muscle.jpg" alt="bodybuilding" /></p>
<p><span style="background-color: rgb(192, 192, 192);"><span style="color: rgb(255, 255, 255);">Transport of Steroids in the Bloodstream</span></span></p>
<p>Once the steroid has been released from the depot (or the oral steroid has been absorbed from the intestine), it is transported throughout the body in the bloodstream. Carrier proteins (Albumin and Sex Hormone binding Globulin) bind about 98% of testosterone under natural conditions. Thus, only 2% of the hormone is free to carry out its actions. When exogenous steroid is present, the level of free steroid is much higher than 2%. Bear in mind that the hormone is not permanently bound to the some of the proteins, but is constantly binding and un-binding from the protein. At any given time, about 2% of the hormone is un-bound in the natural state. So, if the 2% unbound hormone were to magically disappear, then the proteins would release more hormone such that 2% (of the remaining total) would come unbound. The bloodstream is the mechanism by which the hormones reach their target tissues (muscle).</p>
<p><span style="color: rgb(255, 255, 255);"><span style="background-color: rgb(102, 102, 153);">ACTION OF STEROIDS</span></span></p>
<p><span style="color: rgb(255, 255, 255);"><span style="background-color: rgb(192, 192, 192);">Androgen Receptor Activation</span></span></p>
<p>Once a free molecule of steroid reaches the muscle cell, it diffuses into the cell. The diffusion can be with or without transport-protein assistance. Once in the cell, the AAS is makes its way to the cell nucleus where it can bind with an androgen receptor (AR), and activate the receptor. Two of these activated receptor complexes join together to form the androgen response element (ARE). The ARE interacts with DNA in the nucleus, and increases the transcription of certain genes (such as muscle protein genes). As long as the ARE is intact, it accelerates gene transcription. Remember, though, that the AAS and the receptor are in a state of flux (binding and un-binding), just like with the Carrier proteins. So the ARE can be deactivated just by losing one of the two AAS that are bound to the AR&#8217;s. This equilibrium situation explains why 1 gram per week testosterone is more effective than 1/2 gram per week, even though 1/2 gram appears to be more than enough to saturate all the AR&#8217;s in the body. The higher concentration makes it more likely that the receptors will be occupied by an AAS, and the ARE will be intact for a longer period of time, on average.</p>
<p><span style="color: rgb(255, 255, 255);"><span style="background-color: rgb(192, 192, 192);">Other Actions</span></span></p>
<p>Activation of the androgen receptor is a key mechanism in the action of AAS. However, this mechanism by itself does not explain the differences between steroids (i.e., nandrolone activates the AR better than testosterone, but is not as good of a mass-building product). Other actions involve primarily the central nervous system, and involve actions such as motor activation (muscle coordination) and mood (i.e., aggressiveness). The mechanism by which AAS effect these actions is not well understood at this time. Another effect occurs in the liver, where some steroids cause the release of certain Growth Factors. The different actions of the different AAS explains why a stack of two different types of AAS is often better than one by itself.</p>
<p><span style="color: rgb(255, 255, 255);"><span style="background-color: rgb(192, 192, 192);">Elimination of Steroids</span></span></p>
<p>The liver is a primary route to deactivation of steroids, the chemical structure is changed here to make the steroid more soluble in water for excretion through the kidneys. A good portion of many steroids also are excreted as-is, without any alteration by the liver, or by formation of the sulphate, which is more water soluble. Many in the medical community have believed that AAS cause liver damage because levels of certain enzymes (AST and ALT) are elevated when steroids are used. Elevated levels of these enzymes are seen in patients with liver damage from other causes, so the conclusion is that AAS must cause liver damage because these enzymes are elevated. Recent work, however, has shown that a true marker of liver damage, GGT, remains unchanged when some AAS are used, and now it is questioned whether AAS are really damaging to the liver (the 17 alpha-alkylated AAS do cause damage in some rare cases, and this damage is reversible upon cessation of steroid use). The same thought processes were used to claim kidney damage, but that is unlikely as well.</p>
<p>One thing I&#8217;ll say is 1 gram maybe better then 500mg, but the possibilities of side effects would be higher too. Like he said 500mg &quot;appears to be more than enough to saturate all the AR&#8217;s in the body.&quot; Once you go passed what your receptors can handle, the chances of the juice converting to a side effect are very high.</p>
<p>Source: bodybuildingpro.com</p>
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